Most Expensive Places to Live in the U.S. San Francisco consistently ranks among the top most expensive cities in the U.S. True False None Detroit, Michigan, is one of the most expensive places to live in America. True False None Honolulu, Hawaii, has some of the highest living costs in the country. True False None New York City is often ranked as the most affordable big city on the East Coast. True False None Los Angeles is known for its high housing prices and overall cost of living. True False None Time's up Most Popular Most Popular